The drug is a fusion protein comprising the human interleukin (IL)-1 type 1 receptor (extracellular domain and accessory protein) and the Fc portion of human IgG1. Regeneron's drug is the only ...

Experimental models of gouty inflammation have shown that neutrophil influx in response to MSU crystals is reduced in mice deficient in inflammasome components or in the IL-1 receptor (IL1-R1 ...

GlobalData’s report assesses the drugs in the Interleukin 18 Receptor 1 pipeline by therapy areas, indications, stages, MoA, RoA, molecule type and the key players in the development pipeline.

During the last few years of Kobe Bryant's career, the Lakers legend began to head overseas for evaluations on his knee.

T-cell therapy has increased rapidly, the clinical benefit seen with these products comes at a cost for patients who experience toxicities related to the induction of a powerful immune response. The ...

The ED50 is 0.35–1.4 ng/mL. Image Credit: Sino Biological Inc. IL-2 receptors with various subunits have been created to speed up the study of IL-2/IL-2R signaling. Source: Sino Biological Inc ...

Interleukin-2 (IL-2) is a pluripotent cytokine that regulates the immune system’s response. The IL-2 receptor (IL-2R) is a heterotrimeric protein that binds to IL-2 and reacts to it on the ...

IL-17A signals through its receptor, IL-17RA ... including significant upregulation of MCP-1, MCP-5, MIP-2 and KC chemokine secretion. Exogenous IL-17A does not significantly alter the expression ...

Antibodies that interfere with IL-6 function Tocilizumab is a monoclonal antibody directed against the IL-6 receptor that has ... Antibodies that interfere with IL-1 function Anakinra interferes ...

Why Trust Us? GLP-1 receptor agonists like Ozempic and Wegovy have a lot of scientific data to support their use—and they can help people drop a lot of pounds. But is it possible to get the same ...

A large study of veterans with type 2 diabetes finds better short-term kidney outcomes with use of SGLT2 inhibitors vs GLP-1 receptor agonists.